Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18.

ABSTRACT: Expression of Regulated endocrine specific protein 18 (Resp18) is localized in numerous tissues and cell types; however, its exact cellular function is unknown. We previously showed that targeted disruption of the Resp18 locus in the Dahl SS (SS) rat (Resp18^mutant) results in higher blood pressure (BP), increased renal fibrosis, increased urinary protein excretion, and decreased mean survival time following a chronic (6 weeks) 2% high salt (HS) diet compared with the SS rat. Based on this prominent renal injury phenotype, we hypothesized that targeted disruption of Resp18 in the SS rat promotes an early onset hypertensive-signaling event through altered signatures of the renal transcriptome in response to HS. To test this hypothesis, both SS and Resp18^mutant rats were

SUBMITTER: Ashraf UM 

PROVIDER: S-EPMC8528512 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature