Innate and adaptive abnormalities in youth with vertically acquired HIV through a multicentre cohort in Spain.

ABSTRACT:

Introduction

Immune abnormalities have been described among youth with vertically acquired HIV (YWVH) despite antiretroviral treatment (ART). The CD4/CD8 ratio could be a useful prognostic marker. We assess immune activation and senescence in a cohort of YWVH in comparison to youth without vertically acquired HIV.

Methods

YWVH under suppressive ART were included and compared to a group of HIV-negative donors (HD) matched by age and sex, from September 2019 to September 2020. Subset distribution and expression of activation, maturation, senescence and exhaustion markers on T and NK cells were studied on peripheral blood mononuclear cells by multiparametric flow cytometry.

Results

Thirty-two YWVH (median age: 24.4 years (interquartile range: 22.5 to 28.3 years)) were in

SUBMITTER: Carrasco I 

PROVIDER: S-EPMC8528666 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature