An attempt to dissect a peripheral marker based on cell pathology in Parkinson's disease.

ABSTRACT: Peripheral markers in Parkinson's disease (PD) represent a hot issue to provide early diagnosis and assess disease progression. The gold standard marker of PD should feature the same reliability as the pathogenic alteration, which produces the disease itself. PD is foremost a movement disorder produced by a loss of nigrostriatal dopamine innervation, in which striatal dopamine terminals are always markedly reduced in PD patients to an extent, which never overlaps with controls. Similarly, a reliable marker of PD should possess such a non-overlapping feature when compared with controls. In the present study, we provide a novel pathological hallmark, the autophagosome, which in each PD patient was always suppressed compared with each control subject. Autophagosomes were counted as microtubul

SUBMITTER: Biagioni F 

PROVIDER: S-EPMC8528800 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature