Clinical Utility of SPECT in the Heart Transplant Population: Analysis From a Single Large-volume Center.

ABSTRACT:

Background

Survival after heart transplant has greatly improved, with median survival now over 12 years. Cardiac allograft vasculopathy (CAV) has become a major source of long-term morbidity and mortality. Single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is used for CAV surveillance, but there is limited data on its prognostic utility.

Methods

We retrospectively identified patients undergoing SPECT MPI for CAV surveillance at a single, large-volume center. Images were assessed with semiquantitative visual scoring (summed stress score [SSS] and summed rest score) and quantitatively with total perfusion defect (TPD).

Results

We studied 503 patients (mean age 62.5, 69.3% male) at a median of 9.0 years post-transplant. During mean foll

SUBMITTER: Aguilar J 

PROVIDER: S-EPMC8528902 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature