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The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia.


ABSTRACT: Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.

SUBMITTER: Goldsmith DR 

PROVIDER: S-EPMC8528914 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia.

Goldsmith David R DR   Massa Nicholas N   Miller Brian J BJ   Miller Andrew H AH   Duncan Erica E  

NPJ schizophrenia 20211020 1


Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relatio  ...[more]

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