Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection.

ABSTRACT: Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host resistance to pathogens. We have recently shown that Tpl2^-/- mice succumb to infection with a low-pathogenicity strain of influenza (x31, H3N2) by an unknown mechanism. In this study, we sought to characterize the cytokine and immune cell profile of influenza-infected Tpl2^-/- mice to gain insight into its host protective effects. Although Tpl2^-/- mice display modestly impaired viral control, no virus was observed in the lungs of Tpl2^-/- mice on the day of peak morbidity and m

SUBMITTER: Latha K 

PROVIDER: S-EPMC8529111 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature