Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma.

ABSTRACT:

Backgrounds

Gastric cancer is one of the most common cancers with unsatisfied prognosis. It is challenging to predict gastric cancer prognosis due to its highly heterogeneous nature. Kallikrein 5 (KLK5) belongs to the family of kallikreins, which plays a crucial role in serine proteolysis and exerts diverse physiological functions. The role of KLK5 in human gastric adenocarcinoma (GAC) has not been elucidated. In the present study, we aimed to examine the expression level of KLK5 and dissect whether the KLK5 expression was associated with GAC prognosis.

Patients and methods

Clinicopathological analyses were performed in a retrospective GAC patient cohort (n = 138). The expression of KLK5 was tested by quantitative RT-PCR and immunohistochemistry staining. The prognostic role

SUBMITTER: Abuduhadeer X 

PROVIDER: S-EPMC8529136 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature