VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis.

ABSTRACT: V-domain Ig suppressor of T cell activation (VISTA) is a novel coinhibitory immune checkpoint molecule that maintains immune homeostasis. The present study explored the role of VISTA in human and murine inflammatory tissues of apical periodontitis (AP). VISTA was upregulated in inflammatory tissues of human AP. In mice, the expression of VISTA gradually increased with the development of mouse experimental apical periodontitis (MAP), the CD3⁺ T cells, CD11b⁺ myeloid cells, and FOXP3⁺ regulatory T cells also gradually accumulated. Moreover, a blockade of VISTA using a mouse in vivo anti-VISTA antibody aggravated periapical bone loss and enhanced the infiltration of immune cells in an experimental mouse periapical periodontitis model. The collective res

SUBMITTER: Yang F 

PROVIDER: S-EPMC8529274 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature