Macrophage-Disguised Manganese Dioxide Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Modulating Inflammatory Microenvironment in Acute Ischemic Stroke.

ABSTRACT: Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic stroke. However, the current clinical treatments are remained on single pathological process, which are due to lack of comprehensive neuroprotective effects. Herein, a macrophage-disguised honeycomb manganese dioxide (MnO₂ ) nanosphere loaded with fingolimod (FTY) is developed to salvage the ischemic penumbra. In particular, the biomimetic nanoparticles can accumulate actively in the damaged brain via macrophage-membrane protein-mediated recognition with cell adhesion molecules that are overexpressed on the damaged vascular endothelium. MnO₂ nanosphere can consume excess hydrogen peroxide (H₂ O₂ ) and convert it into desiderated oxygen (O₂ ), and c

SUBMITTER: Li C 

PROVIDER: S-EPMC8529435 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature