Cardiac-derived TGF-β1 confers resistance to diet-induced obesity through the regulation of adipocyte size and function.

ABSTRACT: Regulation of organismal homeostasis in response to nutrient availability is a vital physiological process that involves inter-organ communication. Understanding the mechanisms controlling systemic cross-talk for the maintenance of metabolic health is critical to counteract diet-induced obesity. Here, we show that cardiac-derived transforming growth factor beta 1 (TGF-β1) protects against weight gain and glucose intolerance in mice subjected to high-fat diet. Secretion of TGF-β1 by cardiomyocytes correlates with the bioavailability of this factor in circulation. TGF-β1 prevents adipose tissue inflammation independent of body mass and glucose metabolism phenotypes, indicating protection from adipocyte dysfunction-driven immune cell recruitment. TGF-β1 alters the gene expression programs in

SUBMITTER: Longenecker JZ 

PROVIDER: S-EPMC8529557 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature