Quantifying value-based determinants of drug and non-drug decision dynamics.

ABSTRACT:

Rationale

A growing body of research suggests that substance use disorder (SUD) may be characterized as disorders of decision making. However, drug choice studies assessing drug-associated decision making often lack more complex and dynamic conditions that better approximate contexts outside the laboratory and may lead to incomplete conclusions regarding the nature of drug-associated value.

Objectives

The current study assessed isomorphic (choice between identical food options) and allomorphic (choice between remifentanil [REMI] and food) choice across dynamically changing reward probabilities, magnitudes, and differentially reward-predictive stimuli in male rats to better understand determinants of drug value. Choice data were analyzed at aggregate and choice-by-choice leve

SUBMITTER: Smith AP 

PROVIDER: S-EPMC8529627 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature