Antioxidant Activity of Natural Samwirin A: Theoretical and Experimental Insights.

ABSTRACT: Samwirin A (SW), a natural compound isolated from Sambucus williamsii or Rourea harmandiana, is known to exhibit potent antiosteoporosis activity and promote cell proliferation in rat osteoblast-like UMR 106 cells. Antiosteoporosis activity suggests that the compound must also exhibit antioxidant activity but this has not been studied thus far. In the present study, the antioxidant activity of SW was examined by experimental and computational studies. It was found that SW exhibits good hydroperoxyl scavenging activity, particularly in water at physiological pH (k _overall = 1.01 × 10⁷ M^-1 s^-1). The single-electron transfer mechanism defines the HOO^• + SW reaction in water, while the activity in

SUBMITTER: Dinh Ngoc T 

PROVIDER: S-EPMC8529648 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature