Photodissociation Dynamics of Nitric Oxide from N-Acetylcysteine- or N-Acetylpenicillamine-bound Roussin's Red Ester.

ABSTRACT: The photochemical release of nitric oxide (NO) from a NO precursor is advantageous in terms of spatial, temporal, and dosage control of NO delivery to target sites. To realize full control of the quantitative NO administration from photoactivated NO precursors, it is necessary to have detailed dynamical information on the photodissociation of NO from NO precursors. We synthesized two new water-soluble Roussin's red esters (RREs), [Fe₂(μ-N-acetylcysteine)₂(NO)₄] and [Fe₂(μ-N-acetylpenicillamine)₂(NO)₄], which have five times longer lifetime than the well-known [Fe₂(μ-cysteine)₂(NO)₄]. The photodissociation dynamics of NO from these RREs in water were investigated over a broad tim

SUBMITTER: Yoon H 

PROVIDER: S-EPMC8529681 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature