Epigenetic interplay between methylation and miRNA in bladder cancer: focus on isoform expression.

ABSTRACT:

Background

Various epigenetic factors are responsible for the non-genetic regulation on gene expression. The epigenetically dysregulated oncogenes or tumor suppressors by miRNA and/or DNA methylation are often observed in cancer cells. Each of these epigenetic regulators has been studied well in cancer progressions; however, their mutual regulatory relationship in cancer still remains unclear. In this study, we propose an integrative framework to systematically investigate epigenetic interactions between miRNA and methylation at the alternatively spliced mRNA level in bladder cancer. Each of these epigenetic regulators has been studied well in cancer progressions; however, their mutual regulatory relationship in cancer still remains unclear.

Results

The integrative analyses

SUBMITTER: Shivakumar M 

PROVIDER: S-EPMC8529714 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature