Long-term predictors of severe exacerbations and mortality in a cohort of well-characterised adults with asthma.

ABSTRACT:

Background

We aimed to explore long-term predictors of severe exacerbations and mortality in adults with well-characterised asthma.

Study design and methods

Adults (aged ≥ 15) with an objectively verified diagnosis of asthma were recruited from a Danish respiratory outpatient clinic between 1974 and 1990. All individuals were followed in Danish registries for vital status, hospital admissions for asthma and cause of death until end of 2017. Predictors of exacerbations were obtained from a repeated measures model. Standardised mortality rates (SMR) for all-causes were compared with the Danish background population. Hazard ratios for mortality were obtained from a cox proportional hazards model in a two-step process.

Results

At baseline, the cohort comprised 1071 patien

SUBMITTER: Tupper OD 

PROVIDER: S-EPMC8529759 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature