Clinical verification of body mass index and tumor immune response in patients with breast cancer receiving preoperative chemotherapy.

ABSTRACT:

Purpose

The body mass index (BMI) is commonly used as a simple indicator of obesity; patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrence and low survival rates. On the other hand, it has been shown that lymphocytes present in the vicinity of malignant growths that are involved in the tumors' immune responses influence the efficacy chemotherapy. Therefore, we hypothesized that OB patients with breast cancer have a lower density of tumor-infiltrating lymphocytes (TILs), which may influence the therapeutic effect of preoperative chemotherapy (POC). In this study, we measured pretreatment BMI and TILs in patients with breast cancer who underwent POC, examined the correlations between these two factors, an

SUBMITTER: Takada K 

PROVIDER: S-EPMC8529767 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature