Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension.

ABSTRACT: Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endothelium to affect blood pressure. Recently we discovered a T-cell subset expressing ChAT (T_ChAT), whereby genetic ablation of ChAT in these cells produces hypertension, indicating that production of ACh by T_ChAT regulates blood pressure. Accordingly, we reasoned that increasing systemic ChAT concentrations might induce vasodilation and reduce blood pressure. To evaluate this possibility, recombinant ChAT was administered intraperitoneally to mice having angiotensin II-induced hypertension

SUBMITTER: Stiegler A 

PROVIDER: S-EPMC8529785 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature