Association between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients.

ABSTRACT:

Background

Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic candidate genes according to the Kyoto encyclopedia of genes and genomes - pathway: cholinergic neurotransmission with the development of POD or POCD in elderly patients.

Methods

This analysis is part of the European BioCog project ( www.biocog.eu ), a prospective multicenter observational study with elderly surgical patients. Patients with a Mini-Mental-State-Examination score ≤ 23 points were excluded. POD was assessed up to seven days after surgery using the Nursing Delirium Screening Scale, Confusion Assessment Method and a patient chart review. POCD was a

SUBMITTER: Heinrich M 

PROVIDER: S-EPMC8529799 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature