Causal relationship between educational attainment and the risk of rheumatoid arthritis: a Mendelian randomization study.

ABSTRACT:

Background

Educational attainment is moderately heritable and inversely associated with the risk of rheumatoid arthritis. However, the causality from educational attainment on rheumatoid arthritis remained unknown. Here, we aimed to determine whether educational attainment is causally associated with rheumatoid arthritis (RA) by using Mendelian randomization (MR) approach.

Methods

Summary statistics data for RA were obtained from an available, published meta-analysis of genome-wide association studies (GWAS) that included 14,361 RA cases and 43,923 controls of European ancestry. The instrumental variables for educational attainment were obtained from a GWAS meta-analysis that included over 1 million individuals (N = 1,131,881) of European ancestry. MR analyses were mainly pe

SUBMITTER: Huang G 

PROVIDER: S-EPMC8529827 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature