Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial cancers.

ABSTRACT:

Background

The V-Akt murine thymoma viral oncogene (AKT) 1 (E17K) is a subfamily of serine/threonine protein kinases that affects the survival, proliferation, and invasion of cancer cells. The clinicopathological features and frequencies in Asian populations with AKT1 mutations in breast and endometrial cancers are unclear. Hence, we aimed to determine the frequencies and relationships between clinicopathological features and AKT1 mutations in Asian women with cancer.

Methods

We extracted DNA from 311 and 143 samples derived from patients with breast and endometrial cancers to detect the AKT1 point mutation (hotspot), E17K. We examined correlations between clinicopathological features and AKT1 mutation status.

Results

The frequency of AKT1 mutations in breast cancer w

SUBMITTER: Shimoi T 

PROVIDER: S-EPMC8529845 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature