Hydroxyl Radical Production by Air Pollutants in Epithelial Lining Fluid Governed by Interconversion and Scavenging of Reactive Oxygen Species.

ABSTRACT: Air pollution is a major risk factor for human health. Chemical reactions in the epithelial lining fluid (ELF) of the human respiratory tract result in the formation of reactive oxygen species (ROS), which can lead to oxidative stress and adverse health effects. We use kinetic modeling to quantify the effects of fine particulate matter (PM2.5), ozone (O₃), and nitrogen dioxide (NO₂) on ROS formation, interconversion, and reactivity, and discuss different chemical metrics for oxidative stress, such as cumulative production of ROS and hydrogen peroxide (H₂O₂) to hydroxyl radical (OH) conversion. All three air pollutants produce ROS that accumulate in the ELF as H₂O₂, which serves as reservoir for radical species. At low PM2.5

SUBMITTER: Lelieveld S 

PROVIDER: S-EPMC8529872 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature