Ontology highlight
ABSTRACT:
SUBMITTER: Qin Z
PROVIDER: S-EPMC8529884 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Qin Zhen Z Dong Bin B Wang Renbing R Huang Dechun D Wang Jubo J Feng Xi X Bian Jinlei J Li Zhiyu Z
Acta pharmaceutica Sinica. B 20211021 11
EIDD-2801 is an orally bioavailable prodrug, which will be applied for emergency use authorization from the U.S. Food and Drug Administration for the treatment of COVID-19. To investigate the optimal parameters, EIDD-2801 was optimized <i>via</i> a four-step synthesis with high purity of 99.9%. The hydroxylamination procedure was telescoped in a one-pot and the final step was precisely controlled on reagents, temperature and reaction time. Compared to the original route, the yield of the new rou ...[more]