Design, Synthesis, and Biological Activity of Novel Ferulic Amide Ac5c Derivatives.

ABSTRACT: A total of 34 novel ferulic amide Ac5c derivatives were designed and synthesized and their antipest activities were investigated. The results showed that some compounds exhibited excellent in vitro antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo) and X. oryzae pv. oryzicola (Xoc), such as compounds 4q and 5n demonstrated excellent in vitro activity against Xoo, with EC₅₀ values of 4.0, and 1.9 μg/mL, respectively. Compounds 4c, 4h, 4m, 4p, 4q, and 5a had significant in vitro activities against Xoc, with EC₅₀ values of 12.5, 13.9, 9.8 15.0, 9.2, and 19.8 μg/mL, respectively. Moreover, the antibacterial activity in viv

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8529889 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature