Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.

ABSTRACT: Peripheral nerve injury repair requires a certain degree of cooperation between axon regeneration and Wallerian degeneration. Therefore, investigating how axon regeneration and degeneration work together to repair peripheral nerve injury may uncover the molecular mechanisms and signal cascades underlying peripheral nerve repair and provide potential strategies for improving the low axon regeneration capacity of the central nervous system. In this study, we applied weighted gene co-expression network analysis to identify differentially expressed genes in proximal and distal sciatic nerve segments from rats with sciatic nerve injury. We identified 31 and 15 co-expression modules from the proximal and distal sciatic nerve segments, respectively. Functional enrichment analysis revealed that th

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8530115 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature