The Association of Platelet Decrease Following Continuous Renal Replacement Therapy Initiation and Increased Rates of Secondary Infections.

ABSTRACT:

Objectives

Thrombocytopenia is common in critically ill patients treated with continuous renal replacement therapy and decreases in platelets following continuous renal replacement therapy initiation have been associated with increased mortality. Platelets play a role in innate and adaptive immunity, making it plausible that decreases in platelets following continuous renal replacement therapy initiation predispose patients to development of infection. Our objective was to determine if greater decreases in platelets following continuous renal replacement therapy correlate with increased rates of secondary infection.

Design

Retrospectivecohort analysis.

Setting

This study uses a continuous renal replacement therapy database from Mayo Clinic (Rochester, MN), a tertiary

SUBMITTER: Griffin BR 

PROVIDER: S-EPMC8530244 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature