The role of platelets in thrombus fibrosis and vessel wall remodeling after venous thrombosis.

ABSTRACT:

Purpose

Platelets are known to play an important role in venous thrombogenesis, but their role in thrombus maturation, resolution, and postthrombotic vein wall remodeling is unclear. The purpose of this study was to determine the role that circulating platelets play in the later phases of venous thrombosis.

Methods

We used a murine inferior vena cava (IVC) stenosis model. Baseline studies in untreated mice were performed to determine an optimal postthrombotic time point for tissue harvest that would capture both thrombus maturation/resolution and postthrombotic vein wall remodeling. This time point was found to be postoperative day 10. After undergoing IVC ultrasound on day 2 to confirm venous thrombus formation, mice were treated with a daily injection of platelet-depleting

SUBMITTER: DeRoo E 

PROVIDER: S-EPMC8530247 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature