Low-Dose High-Resolution TOF-PET Using Ionization-activated Multi-State Low-Z Detector Media.

ABSTRACT: We propose PET scanners using low atomic number media that undergo a persistent local change of state along the paths of the Compton recoil electrons. Measurement of the individual scattering locations and angles, deposited energies, and recoil electron directions allows using the kinematical constraints of the 2-body Compton scattering process to perform a statistical time-ordering of the scatterings, with a high probability of precisely identifying where the gamma first interacted in the detector. In these cases the Line-of-Response is measured with high resolution, determined by the underlying physics processes and not the detector segmentation. There are multiple such media that act through different mechanisms. As an example in which the change of state is quantum-mechanical through a

SUBMITTER: Shida JF 

PROVIDER: S-EPMC8530277 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature