Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2.

ABSTRACT: A dysregulated or exacerbated inflammatory response is thought to be the key driver of the pathogenesis of severe disease caused by the mosquito-borne dengue virus (DENV). Compounds that restrict virus replication and modulate the inflammatory response could thus serve as promising therapeutics mitigating the disease pathogenesis. We and others have previously shown that macrophages, which are important cellular targets for DENV replication, differentiated in the presence of bioactive vitamin D (VitD3) are less permissive to viral replication, and produce lower levels of pro-inflammatory cytokines. Therefore, we here evaluated the extent and kinetics of innate immune responses of DENV-2 infected monocytes differentiated into macrophages in the presence (D3-MDMs) or absence of VitD3 (MDMs).

SUBMITTER: Castillo JA 

PROVIDER: S-EPMC8530315 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature