Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study.

ABSTRACT: Amotivation is related to value representation. A comprehensive account of amotivation requires a mechanistic understanding of how the brain exploits external information to represent value. To achieve maximal value discriminability, brain valuation system will dynamically adapt its coding sensitivity to the range of values available in any given condition, so-called range adaptive coding. We administered an experimental task to 30 patients with chronic schizophrenia (C-SCZ), 30 first-episode schizophrenia (FE-SCZ), 34 individuals with high social anhedonia (HSoA), and their paired controls to assess range adaptation ability. C-SCZ patients exhibited over-adaptation and their performances were negatively correlated with avolition symptoms and positive symptoms and positively correlated wit

SUBMITTER: Wang LL 

PROVIDER: S-EPMC8530390 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature