Validation of a Questionnaire to Identify Respiratory Tract Infections in Children With Sickle Cell Disease.

ABSTRACT:

Background

No validated questionnaires have been published that are specific for identifying respiratory infections in children with sickle cell disease (SCD).

Methods

A questionnaire was developed that included 6 respiratory symptoms (difficulty breathing, wheezing, fever, cough, runny or stuffy nose, and sore throat) to identify respiratory events for a clinical trial. The questionnaire results were compared with identification of viral respiratory pathogens from nasal samples by reverse transcriptase polymerase chain reaction.

Results

Eighty questionnaire responses (40 with symptom/s and 40 without) paired with isolation of viral respiratory pathogen from nasal samples were obtained from 53 children with SCD, ages 4 to 18 years over 2 separate periods in different

SUBMITTER: De A 

PROVIDER: S-EPMC8530454 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature