Ex Vivo Intact Tissue Analysis Reveals Alternative Calcium-sensing Behaviors in Parathyroid Adenomas.

ABSTRACT:

Context

The biochemical basis for clinical variability in primary hyperparathyroidism (PHPT) is poorly understood.

Objective

This study aimed to define parathyroid tumor biochemical properties associated with calcium-sensing failure in PHPT patients, and to relate differences in these profiles to variations in clinical presentation.

Methods

Preoperative clinical data from a sequential series of 39 patients undergoing surgery for PHPT at an endocrine surgery referral center in a large, public university hospital were evaluated for correlation to parathyroid tumor biochemical behavior. An intact tissue, ex vivo interrogative assay was employed to evaluate the calcium-sensing capacity of parathyroid adenomas relative to normal donor glands. Tumors were functionally class

SUBMITTER: Koh J 

PROVIDER: S-EPMC8530711 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature