Breast Cancer Risk Factors and Circulating Anti-Mullerian Hormone Concentration in Healthy Premenopausal Women.

ABSTRACT: We previously reported that anti-Müllerian hormone (AMH), a marker of ovarian reserve, is positively associated with breast cancer risk, consistent with other studies. This study assessed whether risk factors for breast cancer are correlates of AMH concentration. This cross-sectional study included 3831 healthy premenopausal women (aged 21-57, 87% aged 35-49) from 10 cohort studies among the general population. Adjusting for age and cohort, AMH positively associated with age at menarche (P < 0.0001) and parity (P = 0.0008) and inversely associated with hysterectomy/partial oophorectomy (P = 0.0008). Compared with women of normal weight, AMH was lower (relative geometric mean difference 27%, P < 0.0001) among women who were obese. Current oral contraceptive (OC) use and current/former smoki

SUBMITTER: Clendenen TV 

PROVIDER: S-EPMC8530718 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature