Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study.

ABSTRACT:

Context

Iron overload is a known risk factor for type 2 diabetes (T2D); however, iron overload and iron deficiency have both been associated with metabolic disorders in observational studies.

Objective

Using mendelian randomization (MR), we assessed how genetically predicted systemic iron status affected T2D risk.

Methods

A 2-sample MR analysis was used to obtain a causal estimate. We selected genetic variants strongly associated (P < 5 × 10-8) with 4 biomarkers of systemic iron status from a study involving 48 972 individuals performed by the Genetics of Iron Status consortium and applied these biomarkers to the T2D case-control study (74 124 cases and 824 006 controls) performed by the Diabetes Genetics Replication and Meta-analysis consortium. The simple median, we

SUBMITTER: Wang X 

PROVIDER: S-EPMC8530720 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature