Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy.

ABSTRACT:

Context

Lipodystrophy syndromes are rare disorders of deficient adipose tissue, low leptin, and severe metabolic disease, affecting all adipose depots (generalized lipodystrophy, GLD) or only some (partial lipodystrophy, PLD). Left ventricular (LV) hypertrophy is common (especially in GLD); mechanisms may include hyperglycemia, dyslipidemia, or hyperinsulinemia.

Objective

Determine effects of recombinant leptin (metreleptin) on cardiac structure and function in lipodystrophy.

Methods

Open-label treatment study of 38 subjects (18 GLD, 20 PLD) at the National Institutes of Health before and after 1 (N = 27), and 3 to 5 years (N = 23) of metreleptin. Outcomes were echocardiograms, blood pressure (BP), triglycerides, A1c, and homeostasis model assessment of insulin resist

SUBMITTER: Nguyen ML 

PROVIDER: S-EPMC8530723 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature