Hepatic Fat in Participants With and Without Incident Diabetes in the Diabetes Prevention Program Outcome Study.

ABSTRACT:

Context

There is little information about fatty liver in prediabetes as it transitions to early diabetes.

Objective

This study is aimed at evaluating the prevalence and determinants of fatty liver in the Diabetes Prevention Program (DPP).

Methods

We measured liver fat as liver attenuation (LA) in Hounsfield units (HU) in 1876 participants at ~14 years following randomization into the DPP, which tested the effects of lifestyle or metformin interventions versus standard care to prevent diabetes. LA was compared among intervention groups and in those with versus without diabetes, and associations with baseline and follow-up measurements of anthropometric and metabolic covariates were assessed.

Results

There were no differences in liver fat between treatment groups

SUBMITTER: Goldberg RB 

PROVIDER: S-EPMC8530730 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature