Hepatic Fat in Early Childhood Is Independently Associated With Estimated Insulin Resistance: The Healthy Start Study.

ABSTRACT:

Background

Fatty liver disease is a common metabolic abnormality in adolescents with obesity but remains understudied in early childhood.

Objectives

To describe hepatic fat deposition in prepubertal children and examine cross-sectional associations with metabolic markers and body composition.

Methods

Data were from 286 children ages 4 to 8 years old in the Healthy Start Study, a longitudinal prebirth cohort in Colorado (USA). Assessments included magnetic resonance imaging to quantify hepatic and abdominal fats, fasting blood draws to measure metabolic markers, and air displacement plethysmography to measure body composition (fat mass and fat-free mass).

Results

The median (interquartile range) for hepatic fat was 1.65% (1.24%, 2.11%). Log-transformed hepatic f

SUBMITTER: Cohen CC 

PROVIDER: S-EPMC8530740 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature