Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity.

ABSTRACT:

Context

Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust preclinical thyroid cancer models are needed to adequately develop and study novel therapeutic agents. Patient-derived xenograft (PDX) models may resemble patient tumors by recapitulating key genetic alterations and gene expression patterns, making them excellent preclinical models for drug response evaluation.

Objective

We developed distinct ATC PDX models concurrently with cell lines and characterized them in vitro and in vivo.

Methods

Fresh thyroid tumor from patients with a preoperative diagnosis of ATC was surgically collected and divided for concurrent cell line and PDX model development. Cell lines were created by generating single cells through enzymatic digestion. PDX mo

SUBMITTER: Maniakas A 

PROVIDER: S-EPMC8530744 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature