Analysis of Expression of Different Histone Deacetylases in Autoimmune Thyroid Disease.

ABSTRACT:

Context

Histone deacetylases (HDACs) and histone acetyltransferases (HAT) have an important role in the regulation of gene transcription as well as in the development and function of CD4+Foxp3+ T regulatory (Treg) cells. Our group and others have reported that patients with autoimmune thyroid disease (AITD) show abnormalities in the levels and function of different Treg cell subsets.

Objective

We aimed to analyze the levels of expression of several HDACs and the Tip60 HAT in the thyroid gland and immune cells from patients with AITD.

Methods

The expression of HDAC1-11 and the Tip60 HAT, at RNA and protein levels, were determined in thyroid tissue from 20 patients with AITD and 10 healthy controls and these findings were correlated with clinical data. HDAC9 and Tip60 l

SUBMITTER: Sacristan-Gomez P 

PROVIDER: S-EPMC8530745 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature