Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.

ABSTRACT: We evaluated maternal pregnancy adaptations and their relationships with circulating hormones in women who conceived with or without in vitro fertilization (IVF). Pregnancies were grouped by corpus luteum (CL) number: 1 CL with physiological plasma relaxin concentration (P_RLN; spontaneous pregnancies); 0 CL without circulating RLN (programmed cycles); >1 CL with elevated P_RLN (ovarian stimulation). Major findings were that declines in plasma osmolality (P_osm) and plasma sodium concentration ([Formula: see text]) were comparable in the 1 CL and 0 CL cohorts, correlated with plasma estradiol and progesterone concentrations but not P_RLN; gestational declines in plasma uric acid (UA) concentration (P_UA) were attenuated after IVF, especiall

SUBMITTER: Conrad KP 

PROVIDER: S-EPMC8530757 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature