Denoising of hyperpolarized ¹³ C MR images of the human brain using patch-based higher-order singular value decomposition.

ABSTRACT:

Purpose

To improve hyperpolarized ¹³ C (HP-¹³ C) MRI by image denoising with a new approach, patch-based higher-order singular value decomposition (HOSVD).

Methods

The benefit of using a patch-based HOSVD method to denoise dynamic HP-¹³ C MR imaging data was investigated. Image quality and the accuracy of quantitative analyses following denoising were evaluated first using simulated data of [1-¹³ C]pyruvate and its metabolic product, [1-¹³ C]lactate, and compared the results to a global HOSVD method. The patch-based HOSVD method was then applied to healthy volunteer HP [1-¹³ C]pyruvate EPI studies. Voxel-wise kinetic modeling was performed on both non-denoised and denoised data to compare the number of voxels

SUBMITTER: Kim Y 

PROVIDER: S-EPMC8530853 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature