Effects of Magnetic Resonance Imaging Targeting on Overdiagnosis and Overtreatment of Prostate Cancer.

ABSTRACT:

Background

It has been suggested that targeting prostate lesions identified on magnetic resonance imaging (MRI) will improve the sensitivity of prostate biopsy for high-grade disease. The clinical significance of high-grade tumors found on MRI but missed on systematic biopsy is open to question.

Objective

To determine the risk of mortality for high-grade cancers identified by MRI targeting in men who had benign systematic biopsy findings.

Design, setting, and participants

We used data from 999 men with negative systematic biopsy and concurrent MRI-targeted biopsy in the National Cancer Institute MRI study. The comparison group consisted of 3056 men followed for 11 yr after negative sextant biopsy in the European Randomized Trial of Screening for Prostate Cancer (ERSPC

SUBMITTER: Vickers AJ 

PROVIDER: S-EPMC8530856 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature