Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review.

ABSTRACT:

Introduction

Long-term effects of early hyperglycemia in VLBW infants are poorly characterized. The objective of this study was to systematically review the effect of early hyperglycemia on growth, metabolic health, and neurodevelopment after neonatal intensive care unit discharge in VLBW infants.

Methods

The systematic review was conducted in accordance with the PRISMA guidelines. A study protocol was registered in PROSPERO (CRD42019123335). Data sources included Ovid MEDLINE, Embase, Cochrane Library, CINAHL, and Scopus. Selected studies included infants with a blood glucose concentration >150 mg/dL (8.3 mmol/L) during the first 28 days of life, a gestational age (GA) <32 weeks, and/or a birth weight <1,500 g and longitudinal data on growth, metabolic health, or neurodevel

SUBMITTER: Paulsen ME 

PROVIDER: S-EPMC8530871 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature