Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults.

ABSTRACT:

Background

Polygenic risk scores (PRS) may enhance risk stratification for coronary heart disease among young adults. Whether a coronary heart disease PRS improves prediction beyond modifiable risk factors in this population is not known.

Methods

Genotyped adults aged 18 to 35 years were selected from the CARDIA study (Coronary Artery Risk Development in Young Adults; n=1132) and FOS (Framingham Offspring Study; n=663). Systolic blood pressure, total and HDL (high-density lipoprotein) cholesterol, triglycerides, smoking, and waist circumference or body mass index were measured at the visit 1 exam of each study, and coronary artery calcium, a measure of coronary atherosclerosis, was assessed at year 15 (CARDIA) or year 30 (FOS). A previously validated PRS for coronary heart d

SUBMITTER: Wells QS 

PROVIDER: S-EPMC8530876 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature