Fatty acid synthase mediates high glucose-induced EGFR activation in oral dysplastic keratinocytes.

ABSTRACT:

Background

Recent studies point to the epidermal growth factor receptor (EGFR) as a critical mediator of type 2 diabetes mellitus (T2DM)-induced renal, cardiac, and ocular complications. T2DM is considered a systemic contributing factor in oral carcinogenesis. Similarly, increased EGFR gene copy number and protein expression strongly predict tumor progression. Yet, the impact of hyperglycemia on EGFR activity in oral potentially malignant disorders remains unclear. We recently reported that fatty acid synthase (FASN), a key de novo lipogenic enzyme, mediates EGFR activation in nicotine-treated oral dysplastic keratinocytes. While in non-malignant tissues FASN expression is extremely low, it is frequently upregulated in several cancers, including oral squamous cell carcinoma. The pr

SUBMITTER: Wisniewski DJ 

PROVIDER: S-EPMC8530891 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature