Increasing plasma glucose before the development of type 1 diabetes-the TRIGR study.

ABSTRACT:

Objective

The β-cell stress hypothesis suggests that increased insulin demand contributes to the development of type 1 diabetes. In the TRIGR trial we set out to assess the profile of plasma glucose and HbA1c before the diagnosis of clinical diabetes compared to nondiabetic children.

Research design and methods

A cohort of children (N = 2159) with an affected first-degree relative and increased HLA risk were recruited 2002-2007 and followed until 2017. To study the relationship between plasma glucose/HbA1c and the development of autoantibodies or clinical disease Kaplan-Meir curves were developed. Mixed models were constructed for plasma glucose and HbA1c separately.

Results

A family history of type 2 diabetes was related to an increase in plasma glucose (p < 0.001).

SUBMITTER: Ludvigsson J 

PROVIDER: S-EPMC8530903 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature