Hyperpolarized ¹²⁹Xe Magnetic Resonance Imaging for Functional Avoidance Treatment Planning in Thoracic Radiation Therapy: A Comparison of Ventilation- and Gas Exchange-Guided Treatment Plans.

ABSTRACT:

Purpose

To present a methodology to use pulmonary gas exchange maps to guide functional avoidance treatment planning in radiation therapy (RT) and evaluate its efficacy compared with ventilation-guided treatment planning.

Methods and materials

Before receiving conventional RT for non-small cell lung cancer, 11 patients underwent hyperpolarized ¹²⁹Xe gas exchange magnetic resonance imaging to map the distribution of xenon in its gas phase (ventilation) and transiently bound to red blood cells in the alveolar capillaries (gas exchange). Both ventilation and gas exchange maps were independently used to guide development of new functional avoidance treatment plans for every patient, while adhering to institutional dose-volume constraints for normal tissues and target

SUBMITTER: Rankine LJ 

PROVIDER: S-EPMC8530914 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature