Prevalence and Landscape of Actionable Genomic Alterations in Renal Cell Carcinoma.

ABSTRACT:

Purpose

We report our experience with next-generation sequencing to characterize the landscape of actionable genomic alterations in renal cell carcinoma (RCC).

Experimental design

A query of our institutional clinical sequencing database (MSK-IMPACT) was performed that included tumor samples from 38,468 individuals across all cancer types. Somatic variations were annotated using a precision knowledge database (OncoKB) and the available clinical data stratified by level of evidence. Alterations associated with response to immune-checkpoint blockade (ICB) were analyzed separately; these included DNA mismatch repair (MMR) gene alterations, tumor mutational burden (TMB), and microsatellite instability (MSI). Data from The Cancer Genome Atlas (TCGA) consortium as well as public d

SUBMITTER: Attalla K 

PROVIDER: S-EPMC8530915 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature