Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas.

ABSTRACT: HSP90 is critical for maintenance of the cellular proteostasis. In cancer cells, HSP90 also becomes a nucleating site for the stabilization of multiprotein complexes including signaling pathways and transcription complexes. Here we described the role of this HSP90 form, referred to as oncogenic HSP90, in the regulation of cytosolic metabolic pathways in proliferating B-cell lymphoma cells. Oncogenic HSP90 assisted in the organization of metabolic enzymes into non-membrane-bound functional compartments. Under experimental conditions that conserved cellular proteostasis, oncogenic HSP90 coordinated and sustained multiple metabolic pathways required for energy production and maintenance of cellular biomass as well as for secretion of extracellular metabolites. Conversely, inhibition of oncoge

SUBMITTER: Calvo-Vidal MN 

PROVIDER: S-EPMC8530929 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature