Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality.

ABSTRACT:

Background & aims

Longitudinal data are scarce regarding the natural history and long-term risk of mortality in children and young adults with biopsy-confirmed non-alcoholic fatty liver disease (NAFLD).

Methods

This nationwide, matched cohort study included all Swedish children and young adults (≤25 years) with biopsy-confirmed NAFLD (1966-2017; n = 718). NAFLD was confirmed histologically from all liver biopsies submitted to Sweden's 28 pathology departments, and further categorized as simple steatosis or steatohepatitis (NASH). Patients with NAFLD were matched to ≤5 general population controls by age, sex, calendar year and county (n = 3,457). To account for shared genetic and early-life factors, we also matched patients with NAFLD to full-sibling comparators. Using Cox re

SUBMITTER: Simon TG 

PROVIDER: S-EPMC8530955 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature