A new approach method for characterizing inter-species toxicodynamic variability.

ABSTRACT: Inter-species differences in toxicodynamics are often a critical source of uncertainty in safety evaluations and typically dealt with using default adjustment factors. In vitro studies that use cells from different species demonstrated some success for estimating the relationships between life span and/or body weight and sensitivity to cytotoxicity; however, no apparent investigation evaluated the utility of these models for risk assessment. It was hypothesized that an in vitro model using dermal fibroblasts derived from diverse species and individuals might be utilized to inform the extent of inter-species and inter-individual variability in toxicodynamics. To test this hypothesis and characterize both inter-species and inter-individual variability in cytotoxicity, concentra

SUBMITTER: Burnett SD 

PROVIDER: S-EPMC8530970 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature